How HMOs Support Your Baby’s Development

Written by Leena Tabaja. Customer Service Coordinator & proud mom of two.

You may have heard of our innovative, first-to-market OPO (oleic-palmitic-oleic) lipids in Niuriss formula and its role in supporting optimal infant nutrition. But have you heard of HMOs (Human Milk Oligosaccharides) and our latest innovative addition, 2'-Fucosyllactose (2'FL)? These complex and naturally occurring sugars in breastmilk are gaining recognition for their vital role in infant development. HMOs have prebiotic properties (think gut health!) and are the most abundant carbohydrate component of breast milk.

Unique to Breast Milk

One of the most fascinating aspects of HMOs like 2'FL is their exclusivity to breast milk. They are not found in cow's milk or traditional infant formulas, making them a truly unique component of the human breast milk nutritional profile. The two most studied and common HMOs, 2'-Fucosyllactose (2'FL) and Lactose-N-neotetraose (LNnT), play pivotal roles in supporting infant growth. The exclusive nature of these HMOs help highlight the importance of natural breast milk and the need to isolate these valuable carbohydrates and incorporate them into infant formula. Given the proven health benefits of human milk, Niuriss continually strives to advance its formula science to closely mimic human milk’s nutritional value.

Functions and Benefits

HMOs are highly active nutrients in the infant gut - they robustly contribute to various aspects of infant health and development. They play a crucial role in preventing harmful bacteria from attaching to the intestinal wall, thereby lowering the risk of infections and strengthening the gut barrier function. 2'-FL's immunomodulatory effects partially explain why breast milk consumption strengthens infant immunity and highlights the need to incorporate this activity into commercial formula.

Additionally, HMOs have been found to act as prebiotics for naturally occurring gut bacteria, which help regulate digestion and ensure the healthy growth of an infant gut microbiome. A growing body of research also suggests HMOs stimulate brain development and normal cognition. We are beginning to understand the truly unique and multifaceted role of 2'-FL in infant growth, well-being and resilience against disease.

Harnessing the Power of HMOs with Niuriss Stage 3

At Niuriss, we recognize the importance of designing infant formula to closely match human breast milk and use our industry leading innovative approach to incorporate breast milk-mimicking ingredients into our products. By integrating 2'-Fucosyllactose (2'FL) into our Stage 3 toddler formula, we aim to provide growing infants with the ongoing benefits of breast milk, supporting optimal growth and development well beyond the breastfeeding stage.

As parents, ensuring your child receives the best nutrition possible is paramount. With HMO/2'FL along with our OPO blend in Niuriss Stage 3, you can rest assured that you are providing your little one with essential nutrients that support their overall health and well-being. This innovative combination emphasizes Niuriss’ commitment to pioneering infant nutrition. Join us in nurturing the future generation with the best possible start in life!

Disclaimer: Please be advised that breastfeeding, when possible, is the optimal choice for infant nutrition. Consult your healthcare provider before transitioning to formula.

References: 

Renwick, Furst et al. 2025. Modulating the developing gut microbiota with 2’-fucosyllactose and pooled human milk oligosaccharides. Microbiome. 13(44): 1-25.

Van den Abbeele, Duysburgh et al. 2019. 2'Fucosyllactose alters the composition and activity of gut microbiota from formula-fed infants receiving complementary feeding in a validated intestinal model. Van den Abbeele, Duysburgh et al. Journal of Functional Foods. 61(1):1-8.

Vasquez, Barranco et al. 2015. Effects if a human milk oligosaccharide, 2'-flucosyllactose, on hippocampal long-term potentiation and learning capabilities in rodents. Journal of Nutritional Biochemistry. 26(5): 455-65.

     Leena Tabaja 
     Customer Service Coordinator
     & proud mom of two